UltraPome

More Views

Allergens

  • Crustacean Free
  • Dairy Free
  • Egg Free
  • Fish Free
  • Gluten Free
  • Peanut Free
  • Soy Free
  • Tree Nuts Free
UltraPome

Availability: In stock

30 capsules
$59.99

Only $2.00 per capsule
90 capsules
$170.97

Only $1.90 per capsule
180 capsules
$323.94

Only $1.80 per capsule
360 capsules
$633.48

Only $1.76 per capsule
OR

Ultra Pome - the Power of Urolithin A, developed by Harvard-trained scientists *

A bottle of Ultra Pome contains 30 clear, vegetarian capsules, a month’s supply at 1 capsule per day.

Each capsule contains at least 8 billion CFU (colony forming units) (at the time of manufacture) and at least 2 billion CFU (at the time of expiry) coming from

  • 250mg of a proprietary blend of pomegranate extract (skin), ellagic acid and
  • 40mg of a powerful proprietary strain of lactobacillus plantarum DSM 6595 (100%)

Product does not contain milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat or soybean. This precision microbiome product is patent protected, is vegan and manufactured in GMP Certified CMOs. Our manufacturing process doesn’t include any raw material of animal source. They do not contain any GMO material and all raw materials are tested for contaminants (virus, bacteria, heavy metals & pesticides) as per US Pharmacopeia and within FDA limits.

Why pomegranates?

Eating a diet rich in fruits and vegetables may lead to a reduction in the risk of several diseases. For pomegranate, both basic and clinical evidence of the benefits of particular classes of bioactive substances have been developed specifically for the juice and juice extracts. Since ancient times, pomegranate has been used for medicinal purposes. Extensive research on bioactive substances in the pomegranate extract has shown potential benefits. This work has progressed in cell culture, human studies, and in some clinical research demonstrating the preventive potential of pomegranate.*

Ellagitannins are bioactive polyphenols present in pomegranate. *

Pomegranate juice obtained by squeezing the whole fruit has the highest concentration of ellagitannins than any commonly consumed juice and contains the unique ellagitannin, punicalagin. Punicalagin is the known largest molecular weight polyphenol. *

Why Ultra Pome?

Pomegranate ellagitannins are not absorbed intact into the blood stream but are hydrolyzed to ellagic acid over several hours in the intestine. Ellagitannins are also metabolized into urolithins by gut flora, which are conjugated in the liver and excreted in the urine.

These urolithins are also bioactive and inhibit prostate cancer cell growth. Research on basic mechanisms of action in cell culture, animal model systems, and limited clinical research in prostate cancer patients has been carried out with pomegranate juice. *

When gut microflora reacts with ellagitannins, Urolithin A is produced. Absorption of Urolithin A is critical to unlocking the full potential power of pomegranate. Unfortunately, bioavailability is very low due to poor gut microbiome and most of the amazing benefits are lost, until now. *

When gut microflora reacts with ellagitannins, Urolithin A is produced. Absorption of Urolithin A is critical to unlocking the full potential power of pomegranate. Unfortunately, bioavailability is very low due to poor gut microbiome and most of the amazing benefits are lost, until now. *

Our team of experts have identified the MUST HAVE GUT MICROBE that converts ellagitannins to ellagic acid which is better absorbed as well as can be converted efficiently to Urolithin A. Inclusion of pomegranate extract containing ellagitannins along with our microbe will improve the bioconversion as well as help in bacterial colonization. Additionally, our expert scientists also found that the pomegranate extract with bacteria combination induces the expression of the Nrf2 gene (the FIX IT GENE, for cell repair) better than found in human liver cells. Nrf2 is a master transcription factor, which regulates the expression of genes required for detoxification.*

Ultra Pome is a powerful blend of Pomegranate Extract and probiotic for the production, bioavailability and conversion of Urolithin A, a precursor for mitochondrial integrity.*

Key Benefits:

  • Powerful combo of prebiotic and probiotic for Urolithin production *
  • Improves bioconversion of Urolithin *
  • Increases the bioavailability of Urolithin in the gut *
  • Pomegranate extract with bacteria combo induces the anti-oxidant pathway, leading to enhanced cell endurance and cell longevity*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. It is recommended that a physician be consulted before taking any supplements. Results not typical and may vary.

More Information
Benefits

This Product


Details

Ultra Pome - the Power of Urolithin A, developed by Harvard-trained scientists *

A bottle of Ultra Pome contains 30 clear, vegetarian capsules, a month’s supply at 1 capsule per day.

Each capsule contains at least 8 billion CFU (colony forming units) (at the time of manufacture) and at least 2 billion CFU (at the time of expiry) coming from

  • 250mg of a proprietary blend of pomegranate extract (skin), ellagic acid and
  • 40mg of a powerful proprietary strain of lactobacillus plantarum DSM 6595 (100%)

Product does not contain milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat or soybean. This precision microbiome product is patent protected, is vegan and manufactured in GMP Certified CMOs. Our manufacturing process doesn’t include any raw material of animal source. They do not contain any GMO material and all raw materials are tested for contaminants (virus, bacteria, heavy metals & pesticides) as per US Pharmacopeia and within FDA limits.

Why pomegranates?

Eating a diet rich in fruits and vegetables may lead to a reduction in the risk of several diseases. For pomegranate, both basic and clinical evidence of the benefits of particular classes of bioactive substances have been developed specifically for the juice and juice extracts. Since ancient times, pomegranate has been used for medicinal purposes. Extensive research on bioactive substances in the pomegranate extract has shown potential benefits. This work has progressed in cell culture, human studies, and in some clinical research demonstrating the preventive potential of pomegranate.*

Ellagitannins are bioactive polyphenols present in pomegranate. *

Pomegranate juice obtained by squeezing the whole fruit has the highest concentration of ellagitannins than any commonly consumed juice and contains the unique ellagitannin, punicalagin. Punicalagin is the known largest molecular weight polyphenol. *

Why Ultra Pome?

Pomegranate ellagitannins are not absorbed intact into the blood stream but are hydrolyzed to ellagic acid over several hours in the intestine. Ellagitannins are also metabolized into urolithins by gut flora, which are conjugated in the liver and excreted in the urine.

These urolithins are also bioactive and inhibit prostate cancer cell growth. Research on basic mechanisms of action in cell culture, animal model systems, and limited clinical research in prostate cancer patients has been carried out with pomegranate juice. *

When gut microflora reacts with ellagitannins, Urolithin A is produced. Absorption of Urolithin A is critical to unlocking the full potential power of pomegranate. Unfortunately, bioavailability is very low due to poor gut microbiome and most of the amazing benefits are lost, until now. *

When gut microflora reacts with ellagitannins, Urolithin A is produced. Absorption of Urolithin A is critical to unlocking the full potential power of pomegranate. Unfortunately, bioavailability is very low due to poor gut microbiome and most of the amazing benefits are lost, until now. *

Our team of experts have identified the MUST HAVE GUT MICROBE that converts ellagitannins to ellagic acid which is better absorbed as well as can be converted efficiently to Urolithin A. Inclusion of pomegranate extract containing ellagitannins along with our microbe will improve the bioconversion as well as help in bacterial colonization. Additionally, our expert scientists also found that the pomegranate extract with bacteria combination induces the expression of the Nrf2 gene (the FIX IT GENE, for cell repair) better than found in human liver cells. Nrf2 is a master transcription factor, which regulates the expression of genes required for detoxification.*

Ultra Pome is a powerful blend of Pomegranate Extract and probiotic for the production, bioavailability and conversion of Urolithin A, a precursor for mitochondrial integrity.*

Key Benefits:

  • Powerful combo of prebiotic and probiotic for Urolithin production *
  • Improves bioconversion of Urolithin *
  • Increases the bioavailability of Urolithin in the gut *
  • Pomegranate extract with bacteria combo induces the anti-oxidant pathway, leading to enhanced cell endurance and cell longevity*
  • The notable variation in intestinal abundance of this strain genus between healthy and diseased, or health-compromised, individuals indicates that Lactobacillus, or at least certain species or genotypes of Lactobacillus, might be useful gut biomarkers. *
  • Cancer is the second leading cause of death in the United States, and those who survive cancer may experience lasting difficulties, including treatment side effects, as well as physical, cognitive, and psychosocial struggles. Naturally-occurring agents from dietary fruits and vegetables have received considerable attention for the prevention and treatment of cancers. These natural agents are safe and cost efficient in contrast to expensive chemotherapeutic agents, which may induce significant side effects. The pomegranate (Punica granatum L.) fruit has been used for the prevention and treatment of a multitude of diseases and ailments for centuries in ancient cultures. Pomegranate exhibits strong antioxidant activity and is a rich source of anthocyanins, ellagitannins, and hydrolysable tannins.*
  • Accumulating research provides extensive evidence related to biological activities of pomegranate-derived products particularly with respect to their anticancer properties. Studies have suggested the whole pomegranate fruit, as well as its juice and oil, as promising chemopreventive/chemotherapeutic agents, as they exert anti-inflammatory, anti-proliferative, and anti-tumorigenic effects by modulating multiple signaling pathways. Considerable data demonstrates the in vitro and in vivo efficacy of pomegranate against cancer growth and promotion.*
  • The effect of fermentation and the impact of simulated gastrointestinal digestion (SGD) of four fermented pomegranate juices with different lactic acid bacteria (LAB) on the biotransformation of phenolic compounds, was studied by scientists. The changes of the antioxidant capacity (AOC) and of LAB growth and survival in different fermented juices were also studied. Two new phenolic derivatives (catechin and α-punicalagin) were identified only in fermented juices. During SGD, the AOC increased together with the phenolic derivatives concentration mainly in the juices fermented with Lactobacillus. These derivatives were formed due to the LAB metabolism of the ellagitannins, epicatechin, and catechin after fermentation and during SGD. *
  • Among the pomegranate ellagitannins, punicalagin, which is the largest polyphenol, having a molecular weight of greater than 1000, is reported to be responsible for more than half the potent antioxidant activity of the juice. Punicalagin is most abundant in the fruit husk as opposed to the juicy seeds (arils) found within the fruit. Ultra Pome’s pomegranate extract is from the skin, to ensure abundancy of punicalagin. Following metabolism by gut flora, urolithins A and B are formed and conjugated in the liver prior to excretion in the urine. Pomegranate fruit extract and its purified ellagitannins inhibit the proliferation of human cancer cells and modulate the inflammatory subcellular signaling pathways and apoptosis (Afaq et al. 2005; Seeram et al. 2005; Adams et al. 2006). *
  • Ellagitannins and their hydrolysis product, ellagic acid, inhibit prostate cancer cell growth through cell-cycle arrest and stimulation of apoptosis (Castonguay et al. 1997; Albrecht et al. 2004; Lansky et al. 2005). In addition, they inhibit the activation of inflammatory pathways including, but not limited to, the NF-κB pathway. Inhibition of angiogenesis has also been demonstrated both in vitro and in vivo for prostate cancer. The universal nature of these mechanisms in common forms of cancer suggests that pomegranate ellagitannins, which have been tested in both prostate and colon cancer cells by our group, may also be useful dietary agents for the prevention and treatment of other forms of cancer, such as breast cancer. *
  • The ellagitannins found in pomegranate fruit are very potent antioxidants, and pomegranate juice exceeds the in vitro antioxidant potency of other common commercial fruit juices (Seeram, Aviram et al. 2008). There are limited treatment options for prostate cancer patients who have undergone primary therapy such as radical prostatectomy with curative intent but who have progressive elevations in their PSA. Pomegranate juice given daily for 2 years to 40 prostate cancer patients with increasing PSA levels provides evidence for the possible utilization of a nontoxic option for prevention or delay of prostate carcinogenesis. It is remarkable that 85% of patients responded to pomegranate juice in this study. Both in vitro and in vivo investigations in prostate cancer models of the molecular mechanisms that may account for these pomegranate juice effects have been explored.*

Ultra Pome and the other probiotics*

  • Ultra Pome is the only probiotic available in the market that targets improved bioconversion of Urolithin A, critical to unleash the full benefits of pomegranates. *
  • Probiotics are among the most difficult active ingredients to formulate – they are sensitive to heat and moisture. They degrade under the best of conditions and this degradation is unpredictable. When mixed with other ingredients, the rate of degradation increases. So with probiotics it is all about stability. Ultra Pome has extensive testing data with proven stability and results.*
  • It is a challenge to get the probiotics to survive the stomach barrier. Most probiotic supplements result in insignificant change in the diversity of bacteria in fecal samples, resulting in minimal to no clinical benefit. Ultra Pome has been expertly designed by leading scientists trained at the Harvard Medical School, has patented blends and extensive data precisely to ensure efficacy.*
  • Bacterial quantities don’t often match what is on the label. Ultra Pome has clearly established levels at the time of manufacture to the time of expiry. Most products in the market falsely exaggerate the levels by only showing the CFU levels at the time of manufacture.*
  • Several common sources of diverse probiotics are not for all – lactose intolerance is a common digestive problem. So yogurts are not for everyone – Ultra Pome is an easy to use supplement – 1 capsule a day.*
  • Most commonly available products on retail shelves focus on maximizing the count of Colony Forming Units, as many strains as possible, or in media that just don’t work. Ultra Pome is a strain-targeted, expertly designed probiotic supplement. *

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. It is recommended that a physician be consulted before taking any supplements. Results not typical and may vary.

Sources:

  • https://www.ncbi.nlm.nih.gov/books/NBK92772/ - Pomegranate Ellagitannins*
  • Pomegranate for Prevention and Treatment of Cancer: An Update Pooja Sharma 1 , Sarah F. McClees 1 and Farrukh Afaq 1,2,*
  • Intestinal Lactobacillus in health and disease, a driver or just along for the ride? Dustin D Heeney, Melanie G Gareau and Maria L Marco- Science Direct*
  • Influence of Fermentation with Different Lactic Acid Bacteria and in Vitro Digestion on the Biotransformation of Phenolic Compounds in Fermented Pomegranate Juices - Estefanía Valero-Cases, Nallely Nuncio-Jauregui, and Mar ́ ía JoséFrutos* Research Group on Food Quality and Safety, Food Technology Department, Miguel Hernandez University, Ctra. Beniel, km 3.2, 03312 Orihuela, Alicante, Spain *
Additional Information

Additional Information

Product Type:: N/A
Made In US Yes
SKU 102175B
Product Type Capsules
Brand Physician's Signature
Dosage No
FAQ

Q: Is it recommended to take UltraPome during pregnancy or while breastfeeding?

A: We recommend that you review all nutritional supplements with your physician prior to use. In particular, pregnant and nursing women should always consult with their primary care physician regarding vitamin intake to ensure that they are not over or under supplementing.*


Q: Is UltraPome safe for children and teenagers?

A: It is recommended that you first consult with a qualified healthcare professional. Most recommendations for daily use are based on an adult.*


* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. It is recommended that a physician be consulted before taking any supplements. Results not typical and may vary.

FDA: No
What you get: No
How to consume: No
Certificates Of Analysis

Certificates Of Authenticity

Reviews
Banners Banners Banners Banners
Visit our Canadian Website or European Website