Resveratrol is W.T. Rawleigh’s French connection - the answer to a phenomenon called the French Paradox. Many have observed that the curious lifestyle followed by the French people. Many smoke heavily, eat lot of saturates fats and cholesterol which should lead to cardiovascular incidences. On the contrary, French life expectancy is much longer than for Americans. While a lot of studies exist to unravel this mystery, several were based upon the assumption that a high consumption of red wine is healthy. Red wine, as opposed to white wine, contains a lot of a substance called resveratrol. This substance is found in several types of fruit, but above all in the skin of red grapes. In a bottle of good quality red wine there is about 10 micrograms resveratrol per litre.
Reveratrol supplements have gained a lot of attention because of its anti-aging and disease-fighting properties. It might be the key ingredient that prevents damage to blood vessels, reduces low density lipoprotein cholesterol and prevents blood clots.*
Resveratrol reduces the systolic blood pressure which typically increases with age causing the arteries to stiffen. It helps produce nitric oxide which causes blood vessels to relax, which causes the blood pressure to lower. When a lot of calories are consumed, the amount of nitric oxide produced diminishes, but resveratrol can completely eliminate this negative effect. The antioxidant and anti inflammatory activity of resveratrol slows down the age-related cognitive issues. It interferes with protein fragments called beta-amyloids which form the plaques that cause Alzheimer’s disease. It sets off a chain of events that help protect brain cells from damage.*
Resveratrol has also shown key benefits for diabetes, especially with relation to increasing insulin. It stops a certain enzyme from turning glucose into sorbitol which is a sugar alcohol. For people who already have diabetes, too much sorbitol can create cell damaging oxidative stress. It activates MPK which is a protein that helps the body to metabolize glucose. When AMPK is activated it helps keep blood sugar levels low. *
Data from Harvard, published for instance in the influential scientific magazine Nature, show that resveratrol in animals prolongs life by 59%, while simultaneously improving physical and cognitive (learning) performance (1). The same laboratory has recently shown that mice which are fed a high calorie intake have better health and a longer life if they receive a resveratrol supplement (2). Furthermore, it has been shown in mice that resveratrol reduces body fat and increases fat burning.
Resveratrol helps protect cartilage from deteriorating. One of the main symptoms of arthritis is cartilage breakdown leading to joint pain. It also helps reduce inflammation that can prevent damage to joints.*
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. It is recommended that a physician be consulted before taking any supplements. Results not typical and may vary.
Sara Fröjdö, Christine Durand, Luciano Pirola (2008) Metabolic effects of resveratrol in mammals--a link between improved insulin action and aging. Curr Aging Sci. Dec, 1(3): 145–151.
Charbel Moussa, Michaeline Hebron, Xu Huang, Jaeil Ahn, Robert A. Rissman, Paul S. Aisen, R. Scott Turner (2017) Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease. J Neuroinflammation; 14: 1. Published online 2017 Jan 3. doi: 10.1186/s12974-016-0779-0
Chih-Chun Chang, Chieh-Yu Chang, Yang-Tzu Wu, Jiung-Pang Huang, Tzung-Hai Yen, Li-Man Hung (2011) Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase J Biomed Sci. 18(1): 47. Published online 2011 Jun 23. doi: 10.1186/1423-0127-18-47
Mobasheri, A., Henrotin, Y., Biesalski, H.-K., & Shakibaei, M. (2012). Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health. International Journal of Molecular Sciences, 13(4), 4202–4232. http://doi.org/10.3390/ijms13044202
Brown, L. Alcoholism: Clinical and Experimental Research, 2009. Linus Pauling Institute: "Resveratrol."
Baur, J.A. Nature, 2006.
Barger, J.L. PLoS One, 2008. Memorial Sloan-Kettering Cancer Center: "Resveratrol."
Van der Spuy, W.J. Nutrition Research Reviews, Sept. 22, 2009.
Karuppagounder, S.S. Neurochemistry International, 2009.
SKU 102168 Product Type Capsules Brand Nutrients for Health Dosage One a Day FAQ
Q: Does Resveratrol taste like Red Wine?
Q: Will the capsule make me feel drunk?
Q: Can children and teenagers take Resveratrol?
A: We recommend that you review all nutritional supplements with your pediatrician prior to use.*
Q: Can pregnant women take Resveratrol?
A: We recommend that you review all nutritional supplements with your physician prior to use. In particular, pregnant and nursing women should always work with their doctors regarding vitamin intake to ensure that they are not over or under supplementing. The safety of use of Resveratrol during pregnancy and breast-feeding hasn’t been established. Don’t use Resveratrol if you’re pregnant or breast-feeding.*